Amine that can't be prepare by Gabriel phthalimide synthesis:
Aniline
Benzyl amine
Methyl amine
Iso butylamine
Tertiary butylamine
please explain
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Amine that can't be prepare by Gabriel phthalimide synthesis:
Aniline
Benzyl amine
Methyl amine
Iso butylamine
Tertiary butylamine
please explain
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But aryl halides do not undergo nucleophilic substitution with the anion formed by the phthalimide.
Hence aniline cannot be prepared by this method.
the thing to note is benzyl amide is not aromatic...as nh2 group is not directly attached to benzene ring...